Replication of a genetic-risk variant associated with Alzheimer's disease's

 
   Lead Investigator:    Judes Poirier
   Institution      :    McGill University
   E-Mail           :    judes.poirier@mcgill.ca
   Proposal ID      :    894



   Proposal Description:
   Using a population isolate from eastern Canada, we identified a genetic           polymorphism that affects tau pathology in the unique cohort of homogenous        subjects.                                                                         Using the GWAS data and pathological measurements from the ADC, we wish to        replicate our finding and extend the analyse to the whole region.                 Using the existing ADC dataset, we wish to replicate the association we           recently observed in large cohort of autopsy-confirmed AD and control cases       derived from a unique population isolate from Eastern Canada..                    To do so, we wish to use the GWAS dataset generated by the ADC  from              autopsy-confirmed AD and control cases for which, plaques and tangles densities   analyses were performed.